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P7C3-A20

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Specification

Cat. No.

SMD1090

Related Diseases

Depression

Product Name

P7C3-A20

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; Click to view more sizes and prices

Price

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Availability

2 Weeks

Description

P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. P7C3-A20 demonstrated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs. P7C3-A20 showed neuroprotective properties in rodent models of Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury and age-related cognitive decline.

CAS Number

1235481-90-9 (free base)

Chemical Formula

C22H19Br2FN2O

Exact Mass

503.98482

Molecular Weight

506.21

Elemental Analysis

C, 52.20; H, 3.78; Br, 31.57; F, 3.75; N, 5.53; O, 3.16

Synonym

P7C3-A20; P7C3A20; P7C3 A20

IUPAC/Chemical Name

N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

InChi Key

XNLTWMQBJFWQOU-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H19Br2FN2O/c1-28-18-4-2-3-17(11-18)26-12-16(25)13-27-21-7-5-14(23)9-19(21)20-10-15(24)6-8-22(20)27/h2-11,16,26H,12-13H2,1H3

SMILES Code

COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1

Appearance

Light yellow solid to semi-solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

1. Literature method: P7C3A20 were dissolved in 5% dextrose (pH 7.0) with 2.5% DMSO and 10% Cremaphor EL (Sigma; C5135). (Ref: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5). 2. This drug may be formulated in DMSO 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.