Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

ORM-10921

Inquiry

Specification

Cat. No.

SMD1627

Related Diseases

Schizophrenia

Related Diseases

Depression

Product Name

ORM-10921

Size

Customizable

Price

Inquiry

Description

ORM-10921 is an α-2c adrenergic receptor antagonist potentially for the treatment of schizophrenia. In the pharmacodynamic microdialysis study, ORM-10921 was found to increase extracellular dopamine levels in prefrontal cortex in the baseline conditions. In the behavioural tests, ORM-10921 displayed potent antidepressant and antipsychotic-like effects in the forced swimming test and prepulse-inhibition models analogously with the previously reported results with structurally different α2C-selective AR antagonist JP-1302.

CAS Number

610782-82-6 (free base)

Chemical Formula

C18H23NO2

Exact Mass

285.1729

Molecular Weight

285.387

Elemental Analysis

C, 75.76; H, 8.12; N, 4.91; O, 11.21

Synonym

ORM-10921; ORM 10921; ORM10921

IUPAC/Chemical Name

(1S,12bS)-1-(methoxymethyl)-1-methyl-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizine

InChi Key

OCUKPFWNSAAHRP-QZTJIDSGSA-N

InChi Code

InChI=1S/C18H23NO2/c1-18(12-20-2)9-5-10-19-11-8-14-13-6-3-4-7-15(13)21-16(14)17(18)19/h3-4,6-7,17H,5,8-12H2,1-2H3/t17-,18-/m1/s1

SMILES Code

C[C@]1(COC)CCCN2CCC3=C(OC4=CC=CC=C43)[C@]12[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.