Obsessive–compulsive Disorder Animal Models
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Obsessive–compulsive Disorder Animal Models

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Ace Therapeutics has been focusing on the development and optimization of animal models of psychiatric diseases for many years, and has established an excellent research platform for the development of antipsychotic drugs. We are committed to providing customized services for autism animal models for mental disease research, helping researchers to achieve their research goals smoothly.

Introduction of Obsessive–compulsive Disorder Animal Models

Obsessive-compulsive disorder (OCD) is a disabling common neuropsychiatric disorder of unknown etiology characterized by disturbing, persistent thoughts, images, or urges that are experienced as intrusive and meaningless and cause marked distress or anxiety (obsessions) and/or excessive repetition of behaviors or mental actions deliberately designed to neutralize such distress (compulsions). Over the past few decades, many attempts have been made to develop animal models of OCD that may help to unravel the genetic, neurochemical, and neuroanatomical basis of the disorder and aid in the development of new treatments methods and describe the mechanisms by which these treatments exert their beneficial effects.

Fig. 1 Simplified neuroanatomic models of corticostriatal circuitry within the human (top) and mouse (bottom) brain.Fig. 1 Simplified neuroanatomic models of corticostriatal circuitry within the human (top) and mouse (bottom) brain. (Monteiro P, et al., 2016)

Animal Modeling Services for OCD

Ace Therapeutics has developed a variety of animal models of OCD through genetic, pharmacologically induced, behavior-based manipulation, and neurodevelopmental approaches that can be used to study key insights about anxiety-like behaviors and abnormal repetitive and compulsive behaviors, including compulsive grooming, sustained responses during reverse learning, and sustained excessive movement could also be used to develop new therapeutic strategies for OCD and other related disorders.

Information on animal models of autism we provide:

Table 1 Animal models of OCD.

Model OCD-relevant characteristics
Genetic
Hoxb8-KO mouse Excessive self-grooming
Sapap3-KO mouse Excessive self-grooming, increased anxiety, impaired reversal learning, impaired habit formation
Slitrk5-knockout mouse Excessive self-grooming, increased anxiety
Spred2-KO mouse Excessive self-grooming
Slc1a1 ST mouse Decreased AMPH response
Slc1a1-OE mouse Increased AMPH response
DAT knockdown mouse Stereotyped syntactic grooming chains
5-HT2C KO mouse Methodical screen chewing, repetitive head dipping
Circuit manipulation
D1-cholera toxin (CT) mice Repetitive selection of actions
OFC-VMS optogenetic stimulation Progressive increase in grooming
LOFC-CS optogenetic stim in Sapap3-KOs Reduced self-grooming
BLA-DLS optogenetic stimulation Progressive increase in self- grooming & anxiety-like behavior
ChAT interneu- ron ablation (DLS) Increased stress-induced grooming, AMPH-induced stereotypies
PV interneuron ablation (DS) Increased stress-induced grooming
Pharmacologic manipulation
Quinpirole Repetitive checking behavior
RU24969 Perseverative hyperlocomotion, PPI deficits
mCPP Increased directional persistence in T-maze rewarded alternation task

Note: Our service list is constantly updated and improved. Please contact us via email for more latest information and related information.

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Ace Therapeutics offers a variety of animal models for studying the genetic, neurochemical and neuroanatomical basis of OCD. Please tell us your project requirements, we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to make an inquiry.

References

  1. Monteiro P, Feng G. Learning From Animal Models of Obsessive-Compulsive Disorder. Biol Psychiatry. 2016, 79(1):7-16.
  2. Chamberlain BL, Ahmar SE. Animal Models for OCD Research. Current Topics in Behavioral Neurosciences. 2021, 55–96.

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