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NV-5138

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Specification

Cat. No.

SMD1048

Related Diseases

Depression

Product Name

NV-5138

Size

100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g

Price

Inquiry

Availability

2 Weeks

Description

NV-5138 is an orally and centrally active small-molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal cortex (mPFC) to mediate its rapid-acting antidepressant effects. A single oral dose of NV-5138 has been found to increase mTORC1 signaling and produce synaptogenesis in the mPFC and to induce rapid antidepressant effects in multiple animal models of depression.

CAS Number

2095886-80-7

Chemical Formula

C7H13F2NO2

Exact Mass

181.0914

Molecular Weight

181.1828

Elemental Analysis

C, 46.40; H, 7.23; F, 20.97; N, 7.73; O, 17.66

Synonym

NV-5138; NV 5138; NV5138;

IUPAC/Chemical Name

Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-

InChi Key

HRFIMCJTDKEPPV-BYPYZUCNSA-N

InChi Code

InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1

SMILES Code

O=C(O)[C@@H](N)CC(C)(C)C(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.