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NKH477

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Specification

Cat. No.

SMD1016

Related Diseases

Depression

Product Name

NKH477

Size

5.0mg; 10.0mg

Price

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Availability

2 Weeks

Description

NKH477 is a potent activator of adenylyl cyclase. NKH477 shows some selectivity for cardiac (type V) adenylyl cyclase. NKH477 stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo.

CAS Number

138605-00-2

Chemical Formula

C28H45ClO8

Exact Mass

544.2803

Molecular Weight

545.11

Elemental Analysis

C, 61.70; H, 8.32; Cl, 6.50; O, 23.48

Synonym

NKH477; NKH 477; NKH-477.

IUPAC/Chemical Name

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-6-yl 4-methylpentanoate hydrochloride

InChi Key

LNEICJSEZPSKSJ-RPBMHHKSSA-N

InChi Code

InChI=1S/C28H44O8.ClH/c1-10-25(7)15-19(31)28(33)26(8)18(30)13-14-24(5,6)22(26)21(35-20(32)12-11-16(2)3)23(34-17(4)29)27(28,9)36-25;/h10,16,18,21-23,30,33H,1,11-15H2,2-9H3;1H/t18-,21-,22-,23-,25-,26-,27+,28-;/m0./s1

SMILES Code

CC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.