Ace Therapeutics is committed to helping you gain a comprehensive understanding of neurotransmitter secretion and metabolism of these markers associated with psychiatric disorders, providing valuable information for your psychiatric research and antipsychotic drug development. We can efficiently and accurately detect changes in neurotransmitter levels in your samples. In addition, we can determine neurotransmitters using high-performance liquid chromatography (HPLC) methods to meet your different needs.

Introduction of Neurotransmitter Analysis in Psychiatry

Neurotransmitter imbalances are commonly associated with anxiety and depression. The development of central nervous system drugs has been hampered by high attrition rates because it is difficult to get the drug into the brain to do what you want it to do. Neuroendocrine and neurochemical theories of psychiatric disorders remain important in understanding the pathophysiology and proposing novel pharmacological interventions. The ability to monitor neurochemical changes in the brain in real-time allows for more accurate and sensitive pharmacokinetic and pharmacodynamic studies.

Fig. 1 Some neurotransmitters associated with anxiety disorders. (Vismara M, et al., 2020)

Neurotransmitter Analysis Services

We offer an electrochemical platform and subsequent neurochemical bioanalytical tools for the analysis of multiple neurotransmitters from a wide range of biological matrices. Our advanced equipment allows us to offer novel analytical techniques and support the simultaneous analysis of low concentrations of multiple neurotransmitters in a single run. In addition, we can develop novel study designs based on your specific needs for sample preparation, quantification and analysis.

Our Neurochemistry Bioanalytical Tools

• HPLC - tandem mass spectrometry
• HPLC - electrochemical detection
• HPLC - fluorescence detection
• RIA / ELISA

We Offer Assays for The Following Endogenous Molecules

• Kynurenine metabolites
• Monoamines (dopamine, serotonin, norepinephrine and metabolites)
• Amino acids (glutamate, GABA, D- and L-serine, cysteine)
• Oxidative stress markers
• Lipids
• Adenosine and other purines
• Glucose and lactic acid
• Polyamines (including putrescine and spermidine)
• MA metabolites (including HVA, 5-HIAA and DOPAC)
• Other molecules of interest are available upon request

Acceptable Sample Types

• Cerebrospinal fluid samples
• Microdialysis fluid
• Brain tissue samples
• Plasma, plasma-free fraction or serum
• In vitro matrices
• Urine
• Other biological tissues
• Other biological fluids

Our Advantages

• Advanced platform, high throughput, more compound information can be identified.
• High-quality database, high accuracy of compound identification
• Strict quality control
• Personalized service

Ace Therapeutics can assay neurotransmitters and metabolites from many different types of psychiatric disease models and provide accurate and detailed data and analytical reports. We are committed to providing you with valuable information in psychiatric disease research and antipsychotic drug development. If you would like to assay other metabolites but have not found them, you can always make an inquiry and our technical staff will communicate with you as soon as possible.

Reference

1. Vismara M, et al. Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview. Brain Sci. 2020, 10(8):564.

• Neurotransmitter Associated Enzymes