Introduction of Neural Rosette Development for Psychiatric Disorders

Neural rosettes are populations of cells arranged radially around a central canal lumen and occur randomly in monolayer cultures of human pluripotent stem cell (hPSC)-derived neural progenitor cells (NPCs). Because the formation of NPC rosettes is thought to mimic the behavior of cells in the early neural tube, these rosettes represent an important in vitro model for studying neural tube morphogenesis.

Neural Rosette Development Services

Ace Therapeutics provides robust models for in vitro studies of psychiatric disorders that mimic human neural tube formation, including 3D hPSC, hESC, or iPSC-derived neural rosettes. The cis-regulatory elements identified in Neural rosettes contain folate-associated CpG, which may be important during neural tube development, as well as variants associated with neurodevelopmental disorders.

It is crucial to develop effective models to study the morphogenetic processes of the neural tube. Our neural rosettes represent an early stage of neural development and could provide a useful tool for studying psychiatric disorders with developmental origins. In addition, NR enhancers are enriched for non-coding single nucleotide polymorphisms associated with risk of psychiatric disorders such as schizophrenia and autism. Furthermore, we can identify its putative target genes and help you discover genes associated with autism spectrum disorders, mental retardation and developmental delays.

Our Process

Our cell model development process includes the culture, observation, evaluation, and differentiation of cells into neurons, and we detect neural rose junctions and neurite growth through morphological examination. In addition, we provide not only multicellular models for psychiatric research and antipsychotic drugs, but also measurements of neurogenesis, including synaptic growth, which can help screen compounds for neuromodulatory, neuroprotective, neuroregenerative, and neurotoxic effects.

What Can We Help You Achieve in Psychiatry?

• Studying the molecular mechanisms and signaling pathways involved in the self-organization of neural tube formation and neural tube closure
• Study of telencephalon development under normal and pathological conditions
• Studying the mechanisms of neurodevelopmental disorders in autism
• Analyzing the key molecular features of neurodevelopmental defects in psychiatric disorders

Why Choose Us?

• High differentiation efficiency and cell purity
• Our team can differentiate your iPSCs, or we can generate the iPSCs you want.
• Fully characterize cells with biomarkers before delivery
• Fast turnaround time
• Cell-based assay services available for drug screening

Ace Therapeutics is committed to helping you understand cellular and molecular mechanisms and potential gene-gene and gene-environment interactions. We aim to help you develop new therapies for psychiatric disorders. If you are interested in this service, please make an inquiry to learn how we can support you in your project.