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Nelotanserin

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Specification

Cat. No.

SMD1340

Related Diseases

Insomnia

Product Name

Nelotanserin

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg

Price

Inquiry

Availability

2 Weeks

Description

Nelotanserin, also known as APD125, is a potent and selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. Nelotanserin has low nanomolar potency on the 5-HT(2A) receptor with at least 30- and 5000-fold selectivity compared with 5-HT(2C) and 5-HT(2B) receptors, respectively. Nelotanserin produced statistically significant improvements in objective parameters of sleep maintenance and sleep consolidation and was well tolerated in adults with primary chronic insomnia.

CAS Number

839713-36-9

Chemical Formula

C18H15BrF2N4O2

Exact Mass

436.0346

Molecular Weight

437.24

Elemental Analysis

C, 49.45; H, 3.46; Br, 18.27; F, 8.69; N, 12.81; O, 7.32

Synonym

APD125; APD-125; APD 125; Nelotanserin

IUPAC/Chemical Name

1-(3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl)-3-(2,4-difluorophenyl)urea

InChi Key

COSPVUFTLGQDQL-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15BrF2N4O2/c1-25-17(13(19)9-22-25)12-8-11(4-6-16(12)27-2)23-18(26)24-15-5-3-10(20)7-14(15)21/h3-9H,1-2H3,(H2,23,24,26)

SMILES Code

O=C(NC1=CC=C(F)C=C1F)NC2=CC=C(OC)C(C3=C(Br)C=NN3C)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.