Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Nelivaptan

Inquiry

Specification

Cat. No.

SMD319

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Nelivaptan

Size

5.0mg; 10.0mg; 25.0mg

Price

Inquiry

Availability

2 Weeks

Description

Nelivaptan is a non-peptide vasopressin receptor antagonist that is selective for the V1B subtype. SSR149415 ameliorates spermatogenesis function in a mouse model of chronic social defeat stress. SSR149415 has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model. SSR149415 blocks aggressive behaviors in hamsters. The combination of V1b antagonist SSR149415 with NTN at individual subthreshold doses shows potential in alcoholism treatment, possibly with less adverse effects.

CAS Number

439687-69-1

Chemical Formula

C30H32ClN3O8S

Exact Mass

629.1599

Molecular Weight

630.109

Elemental Analysis

C, 57.19; H, 5.12; Cl, 5.63; N, 6.67; O, 20.31; S, 5.09

Synonym

Nelivaptan; SSR149415; SR-149415; SR 149415;

IUPAC/Chemical Name

(2S,4R)-1-[(3R)-5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide

InChi Key

NJXZWIIMWNEOGJ-WEWKHQNJSA-N

InChi Code

InChI=1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1

SMILES Code

O=C([C@H]1N([C@]2(C3=CC=CC=C3OC)C(N(S(=O)(C4=CC=C(OC)C=C4OC)=O)C5=C2C=C(Cl)C=C5)=O)C[C@H](O)C1)N(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.