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ND-7001

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Specification

Cat. No.

SMD305

Related Diseases

Anxiety

Product Name

ND-7001

Size

Customizable

Price

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Description

ND-7001is a PDE2 (phosphodiesterase-2) inhibitor in development by Neuro3d for treatment of Alzheimer's disease, as well as depression and anxiety (by targeting the nitric-oxide synthase pathway). It shows an IC50 of 50 nM against PDE2 and good selectivity over PDE3 and PDE4. General safety, tolerability, and pharmacokinetics characteristics were determined to be good in high doses without adverse side effects.

CAS Number

N/A

Chemical Formula

C24H21N3O3

Exact Mass

399.1583

Molecular Weight

399.45

Elemental Analysis

C, 72.17; H, 5.30; N, 10.52; O, 12.02

Synonym

ND-7001; ND7001; ND 7001

IUPAC/Chemical Name

3-(8-methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)benzamide

InChi Key

WYTGWTBNDXWMMB-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H21N3O3/c1-27-20-13-21(30-2)18(15-7-4-3-5-8-15)12-19(20)23(26-14-22(27)28)16-9-6-10-17(11-16)24(25)29/h3-13H,14H2,1-2H3,(H2,25,29)

SMILES Code

O=C(N)C1=CC=CC(C2=NCC(N(C)C3=CC(OC)=C(C4=CC=CC=C4)C=C32)=O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.