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NBI-34041

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Specification

Cat. No.

SMD294

Related Diseases

Anxiety

Product Name

NBI-34041

Size

Customizable

Price

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Description

NBI-34041 is potent and high-affinity CRF1 receptor antagonist. NBI-34041 is safety and efficacy in attenuating elevated stress response. NBI-34041 is effective in reducing endocrine responses to pharmacological and behavioral challenge mediated by CRF(1) receptors. NBI-34041 is safe and does not impair basal regulation of the HPA system but improves resistance against psychosocial stress. NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders.

CAS Number

268545-87-5

Chemical Formula

C22H26Cl2N4

Exact Mass

416.1535

Molecular Weight

417.378

Elemental Analysis

C, 63.31; H, 6.28; Cl, 16.99; N, 13.42

Synonym

NBI-34041; NBI 34041; NBI34041; SB-723620; SB723620; SB 723620

IUPAC/Chemical Name

1-(2,4-dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene

InChi Key

AKFWXFDMKRSYRD-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3

SMILES Code

CCCC(N1C2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=NC(C)=C2)CC1)CCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.