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NAAG

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Specification

Cat. No.

SMD1629

Related Diseases

Schizophrenia

Product Name

NAAG

Size

10.0mg; 50.0mg; 100.0mg; 250.0mg

Price

Inquiry

Availability

2 Weeks

Description

α-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems. Following synaptic release, α-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate. Increasing α-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats. Tumor levels of α-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.

CAS Number

3106-85-2

Chemical Formula

C11H16N2O8

Exact Mass

304.0907

Molecular Weight

304.255

Elemental Analysis

C, 43.42; H, 5.30; N, 9.21; O, 42.07

Synonym

NAAG; α-NAAG; α NAAG; N-Acetylaspartylglutamic Acid; N Acetylaspartylglutamic Acid; α-Spaglumic Acid; α Spaglumic Acid;

IUPAC/Chemical Name

acetyl-L-aspartyl-L-glutamic acid

InChi Key

OPVPGKGADVGKTG-BQBZGAKWSA-N

InChi Code

InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

SMILES Code

OC(CC[C@H](NC([C@H](CC(O)=O)NC(C)=O)=O)C(O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.