Molecular Diagnostics Method Development Services for Psychiatric Disorders

Molecular Diagnostics Method Development Services for Psychiatric Disorders

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Accurate early diagnosis can help mitigate disease progression and provide more effective treatment to improve the quality of life for people with psychiatric disorders. Ace Therapeutics has been a pioneer in the development and application of molecular diagnostic methods for psychiatric disorders for many years. Our advanced high-throughput screening technology and intelligent algorithms enable us to construct a comprehensive solution integrating biomarker discovery and validation, multi-dimensional data analysis, and personalized diagnostic method development. Our experienced experts leverage our expertise to drive innovation and develop molecular diagnostic methods for psychiatric disorders, enabling our clients to develop efficient and sensitive molecular diagnostic tools for psychiatric disorders.

Molecular Diagnostic Basis of Psychiatric Disorders

The occurrence and development of psychiatric disorders are influenced by a multitude of genetic and environmental factors. Molecular diagnostic methods are based on this fundamental principle. By detecting biomarkers specific to psychiatric disorders, such as gene variants and abnormal protein expression, they can accurately determine the risk of the disease and provide valuable decision support for the clinical diagnosis and treatment of psychiatric disorders. These biomarkers are typically directly related to the mechanisms of disease onset and progression, which allows for more accurate and specific diagnostic information to be provided.

Examples of this include:

  • The measurement of D3 dopamine receptor mRNA levels in schizophrenia-associated lymphocytes.
  • The measurement of depression-associated brain-derived neurotrophic factor levels.
  • Identifying of schizophrenia serum profiles as diagnostic and reactive biomarkers using multi-analyte analysis techniques.

Application of Innovative Commercialized Molecular Diagnostic Tools for Psychiatric Disorders

A number of commercially available diagnostic tools have been developed for the diagnosis of different psychiatric disorders. For example,

  • The application of 5-hydroxytryptamine test kit (enzyme immunoassay) to detect 5-HT level in serum can provide an important basis for recognizing depression and confirming its therapeutic effect.
  • VeriPsych™ is an innovative, commercially available, blood-based molecular diagnostic tool designed to aid in the confirmation of the diagnosis of new-onset schizophrenia. VeriPsych is based on the simultaneous measurement of 51 different protein and hormone biomarkers and associated mathematical decision rules. It assists in confirming the diagnosis of schizophrenia by comparing biomarkers in samples suspected of having schizophrenia with samples of confirmed schizophrenia.

How Can We Help You Successfully Develop Innovative Molecular Diagnostics for Psychiatric Disorders?

  • Biomarker discovery and validation

Biomarkers associated with disease states or mechanisms of action of psychotropic drugs will help improve diagnosis and pave the way for more effective treatments. Ace Therapeutics provides comprehensive biomarker development and validation services to provide a scientific basis for early diagnosis, precision treatment, and prognostic assessment of psychiatric disorders. We employ high-throughput screening technologies, in conjunction with public databases and clinical samples, to identify biomarker candidates associated with psychiatric disorders on a systematic basis. Our strategy includes:

  • Genomic techniques are employed to identify genetic variants associated with psychiatric disorders. These may consist of genes that influence brain development and the balance of neurotransmitters.
  • The mRNA expression profiles in brain tissue or blood samples are examined by transcriptomics technology to gain insight into the expression of psychiatric disease-related genes and to develop novel biomarkers.
  • Abnormal protein expression in brain tissue or blood samples is identified by proteomics technology to identify potential biomarkers.
  • Metabolomics techniques are used to search for small molecule metabolites in a variety of complex matrices (e.g., cerebrospinal fluid, blood, urine, saliva, and other body fluids) as potential biomarkers.
  • Identifying abnormal changes in the epigenetic landscape associated with psychiatric disorders through epigenetic techniques to discover potential biomarkers.

In addition, we validate the mechanism of action of the candidate biomarkers in the occurrence and development of psychiatric disorders through in vitro cellular experiments and in vivo animal models to ensure their biological significance and clinical relevance.

  • Development of molecular diagnostic assays

Ace Therapeutics is dedicated to helping customers develop highly sensitive and specific molecular diagnostic methods for accurately measuring changes at the level of various biomolecules, thus providing reliable detection tools for the diagnosis of psychiatric disorders. Our capabilities include:

  • Establish a nucleic acid detection platform based on PCR, sequencing, and microarray to realize high-throughput detection of target biomarkers.
  • Develop protein assays based on enzyme-linked immunosorbent assay (ELISA), mass spectrometry, and other methods for the detection of relevant biochemical indicators.
  • Integration of multiple analytical techniques to build a comprehensive diagnostic suite for different psychiatric disorders.
  • Data analysis and interpretive modeling

Ace Therapeutics helps clients develop personalized diagnostic prediction models by building diagnostic databases containing multi-dimensional data such as genes, epigenetics, neurotransmitters, etc., and constructing biomarker-integrated diagnostic models for psychiatric disorders using machine learning and intelligent algorithms.

Ace Therapeutics is committed to applying our expertise to provide integrated solutions for the development of preclinical molecular diagnostic methods and technologies for psychiatric disorders. Our team can design and execute the right assay for your study. If you are interested, please feel free to contact us, we will be happy to serve you.


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