Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

MK-8189

Inquiry

Specification

Cat. No.

SMD1588

Related Diseases

Schizophrenia

Product Name

MK-8189

Size

Customizable

Price

Inquiry

Description

MK-8189 is a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. MK-8189 exhibited moderate plasma clearance and relatively low volume of distribution in rats and rhesus monkeys, resulting in a half-life of 4.8 h in rats and 4.2 h in rhesus monkeys. Oral bioavailability ranged from 41% in rhesus monkeys to 46% in rats. MK-8189 has an excellent profile against ion channels (Iks, Cav1.2, and Nav1.5 > 30 μM, and functional hERG Ikr IC50 = 33 μM). MK-8189 was efficacious in a test of episodic memory, the novel objection recognition assay in rats.

CAS Number

1424371-93-6 (SS-isomer)

Chemical Formula

C19H22N6OS

Exact Mass

382.16

Molecular Weight

382.49

Elemental Analysis

C, 59.66; H, 5.80; N, 21.97; O, 4.18; S, 8.38

Synonym

MK-8189; MK8189; MK 8189

IUPAC/Chemical Name

2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine

InChi Key

WQKPZDLZRFTMTI-CABCVRRESA-N

InChi Code

InChI=1S/C19H22N6OS/c1-11-4-5-16(20-8-11)15-6-14(15)10-26-18-7-17(22-12(2)23-18)21-9-19-25-24-13(3)27-19/h4-5,7-8,14-15H,6,9-10H2,1-3H3,(H,21,22,23)/t14-,15+/m1/s1

SMILES Code

CC1=NN=C(CNC2=NC(C)=NC(OC[C@@H]3[C@@H](C4=NC=C(C)C=C4)C3)=C2)S1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.