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MK-8133

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Specification

Cat. No.

SMD1331

Related Diseases

Insomnia

Product Name

MK-8133

Size

Customizable

Price

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Description

MK-8133 is an orexin-2 selective receptor antagonist with favorable development properties. Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders.

CAS Number

1431472-56-8

Chemical Formula

C23H21N5O2

Exact Mass

399.1695

Molecular Weight

399.454

Elemental Analysis

C, 69.16; H, 5.30; N, 17.53; O, 8.01

Synonym

MK-8133; MK 8133; MK8133.

IUPAC/Chemical Name

2-(((3R,6R)-6-methyl-1-(2-(pyrimidin-2-yl)benzoyl)piperidin-3-yl)oxy)isonicotinonitrile

InChi Key

MMRBNOXAAQLWLU-SJLPKXTDSA-N

InChi Code

InChI=1S/C23H21N5O2/c1-16-7-8-18(30-21-13-17(14-24)9-12-25-21)15-28(16)23(29)20-6-3-2-5-19(20)22-26-10-4-11-27-22/h2-6,9-13,16,18H,7-8,15H2,1H3/t16-,18-/m1/s1

SMILES Code

O=C(N1C[C@H](OC2=NC=CC(C#N)=C2)CC[C@H]1C)C(C=CC=C3)=C3C4=NC=CC=N4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.