MK-0249 free base

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MK-0249 free base

Specification
Cat. No.
SMD1558
Related Diseases
Schizophrenia
Product Name
MK-0249 free base
Size
Customizable
Price
Inquiry
Description
MK-0249 is a histamine H3 inverse antagonist. Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. It has been proposed that agents which promote histamine release may enhance cognition and, therefore, the H3 inverse agonist MK-0249 might improve cognitive deficits in patients with schizophrenia.
CAS Number
862309-06-6 (free base)
Chemical Formula
C23H24F3N3O2
Exact Mass
431.1821
Molecular Weight
431.4508
Elemental Analysis
C, 64.03; H, 5.61; F, 13.21; N, 9.74; O, 7.42
Synonym
MK0249; MK 0249; MK-0249
IUPAC/Chemical Name
2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one
InChi Key
DDDZBLNULGDPGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
SMILES Code
O=C1N(C2=CC=C(OCCCN3CCCC3)C=C2)C(C)=NC4=C1C(C(F)(F)F)=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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