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Migrastatin

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Specification

Cat. No.

SMD984

Related Diseases

Depression

Product Name

Migrastatin

Size

1.0mg

Price

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Availability

2 Weeks

Description

Migrastatin is a bacterial metabolite that has been found in Streptomyces with antimuscarinic and anticancer activities. It binds to M1-5 muscarinic acetylcholine receptors and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells, as well as in primary rat bladder smooth muscle cells. Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay. It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.

CAS Number

314245-65-3

Chemical Formula

C27H39NO7

Exact Mass

489.2727

Molecular Weight

489.609

Elemental Analysis

C, 66.24; H, 8.03; N, 2.86; O, 22.87

Synonym

Migrastatin; (+)-Migrastatin; (+) Migrastatin;

IUPAC/Chemical Name

4-((S)-5-((2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl)-4-oxohexyl)piperidine-2,6-dione

InChi Key

OGYMUMAKGYYNHV-IJMHZYIBSA-N

InChi Code

InChI=1S/C27H39NO7/c1-17-14-18(2)27(35-25(32)13-8-6-5-7-12-22(34-4)26(17)33)19(3)21(29)11-9-10-20-15-23(30)28-24(31)16-20/h7-8,12-14,17,19-20,22,26-27,33H,5-6,9-11,15-16H2,1-4H3,(H,28,30,31)/b12-7+,13-8+,18-14-/t17-,19-,22+,26+,27+/m1/s1

SMILES Code

O=C1NC(CC(CCCC([C@@H](C)[C@@]2(/C(C)=C\[C@@H](C)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C(O2)=O)[H])=O)C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.