Microbiome Therapy Development Services for Psychiatric Disorders

Microbiome Therapy Development Services for Psychiatric Disorders

Inquiry

Current studies indicate that probiotics, prebiotics, synbiotics, and fecal transplants have the potential to treat and prevent neurocognitive and certain psychiatric disorders. Ace Therapeutics utilizes our expertise in the field of psychiatric disorders in conjunction with animal models, gut sampling techniques, and tools for reliable identification of gut organisms to comprehensively study the mechanism of action, pharmacokinetics, pharmacodynamics, and the drug microbiome of these emerging microbial therapies. Our experienced team of experts works closely with our clients to help them develop integrated or personalized microbial therapies for the effective treatment of psychiatric disorders.

Bidirectional communication mechanisms between gut microbes and the brain.Fig. 1 Microbiota-gut-brainbidirectional relationship. (Mitrea, L. et al., 2022)

What Can We Offer in Microbiome Therapy Development?

  • Research services on the mechanism of action of microbial therapy

Understanding the various communication pathways on the bidirectional gut-brain axis is crucial for developing new microbial therapeutic strategies. Ace Therapeutics investigates the effects of gut dysbiosis and microbiome alterations on neural pathways and psychiatric phenotypes in psychiatric disorders through preclinical animal models.

  • We evaluate how the microbiota affects the nervous system, including the vagus nerve, HPA axis, production of bacterial metabolites, immune mediators, and gut-endocrine signaling, through advanced neurochemical analyses.
  • We use cutting-edge histological techniques such as genomics, transcriptomics, proteomics, and metabolomics to study the molecular changes induced by microbial therapies.

This helps us identify biomarkers, molecular signatures, and key pathways associated with therapeutic response. These studies clarify the interactions between the gut microbiota and the brain, and aid in the development of microbial therapies for psychiatric disorders.

  • Preclinical development services of microbial therapies

We can help clients evaluate the exact mechanism, efficacy, pharmacokinetics, and safety of known potential probiotic combinations, prebiotics, synbiotics, and fecal transplants for different psychiatric disorders using animal models. We can also help clients screen and customize microbial combinations for different therapeutic purposes and conduct comprehensive evaluations of their efficacy and safety, including behavioral, cognitive, and neurochemical changes, and neural network activity, depending on the demands of our clients. Through rigorous safety assessments, we ensure that microbial therapies meet the highest standards of patient safety.

  • Combination therapy development services

We can develop combination therapies based on microbial therapeutic interventions, including pharmacotherapy, exercise therapy, etc., in combination with microbial therapies according to the demands of our clients. Our experienced experts will work with clients to customize preclinical development strategies for combination therapies and conduct comprehensive evaluations of their efficacy and safety.

Advantages of Our Microbiome Therapy Development Services

  • The comprehensive portfolio of services helps clients to deeply explore how the microbiome affects the development and homeostasis of the central nervous system through immune and neural pathways or routes.
  • Extensive experience in rodent modeling and behavioral testing helps clients comprehensively evaluate the efficacy, safety, and pharmacokinetics of different microbial therapies.
  • Advanced assay technologies and extensive analytical capabilities ensure accurate and valuable preclinical data for our clients.

Ace Therapeutics offers comprehensive support throughout the development of microbial therapies for psychiatric disorders, from early-stage studies to preclinical efficacy assessments. Our commitment is to provide high-quality services and reliable data for your preclinical microbiology studies. Contact us today for more information on developing microbial therapies for psychiatric disorders.

References

  1. Mitrea, L. et al.; Guts imbalance imbalances the brain: a review of gut microbiota association with neurological and psychiatric disorders. Frontiers in Medicine. 9 (2022): 706.
  2. Alagiakrishnan, K.; et al. Microbial therapeutics in neurocognitive and psychiatric disorders. Journal of Clinical Medicine Research. 13.9 (2021): 439.
  3. Pascale, A.; et al. Targeting the microbiota in pharmacology of psychiatric disorders. Pharmacological Research. 157 (2020): 104856.

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