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MGS-0039

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Specification

Cat. No.

SMD266

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

MGS-0039

Size

Customizable

Price

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Description

MGS-0039, also known as BCI-632, is a group II metabotropic glutamate receptor (mgluR2/3) antagonist potentially for the treatment of cognitive disorders, depression and anxiety. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the antidepressant-like action of these compounds. Dopamine release in the NAc shell is regulated by mGlu 2/3 receptors.

CAS Number

569686-87-9

Chemical Formula

C15H14Cl2FNO5

Exact Mass

377.0233

Molecular Weight

378.1774

Elemental Analysis

C, 47.64; H, 3.73; Cl, 18.75; F, 5.02; N, 3.70; O, 21.15

Synonym

MGS-0039; MGS 0039; MGS0039; BCI-632; BCI632; BCI 632

IUPAC/Chemical Name

(1R,2R,3R,5R,6R)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

InChi Key

LFAGGDAZZKUVKO-JAGWWQSPSA-N

InChi Code

InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1

SMILES Code

O=C([C@@]1(N)[C@]2([H])[C@](C(O)=O)(F)[C@]2([H])C[C@H]1OCC3=CC=C(Cl)C(Cl)=C3)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.