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Mexazolam

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Specification

Cat. No.

SMD282

Related Diseases

Anxiety

Product Name

Mexazolam

Size

Customizable

Price

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Description

Mexazolam is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin.

CAS Number

31868-18-5

Chemical Formula

C18H16Cl2N2O2

Exact Mass

362.0589

Molecular Weight

363.238

Elemental Analysis

C, 59.52; H, 4.44; Cl, 19.52; N, 7.71; O, 8.81

Synonym

CS386; CS-386; CS 386; Melex; Sedoxil; Mexazolam

IUPAC/Chemical Name

10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5H)-one

InChi Key

ANUCDXCTICZJRH-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)

SMILES Code

O=C1NC2=CC=C(Cl)C=C2C(OCC3C)(C4=CC=CC=C4Cl)N3C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.