Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Maprotiline-d3 hydrochloride

Inquiry

Specification

Cat. No.

SMD1343

Related Diseases

Insomnia

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Maprotiline-d3 hydrochloride

Size

1.0mg; 5.0mg

Price

Inquiry

Availability

2 Weeks

Description

Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.

CAS Number

1329496-63-0 (hydrochloride)

Chemical Formula

C20H21D3ClN

Exact Mass

316.1786

Molecular Weight

316.8873

Elemental Analysis

C, 75.81; H, 8.59; Cl, 11.19; N, 4.42

Synonym

Maprotiline-d3 hydrochloride; Maprotiline d3 hydrochloride; Ba 34276-d3; Ba34276-d3; Ba-34276-d3; Ba 34276 d3;

IUPAC/Chemical Name

3-(9,10-ethanoanthracen-9(10H)-yl)-N-(methyl-d3)propan-1-amine hydrochloride

InChi Key

NZDMFGKECODQRY-NIIDSAIPSA-N

InChi Code

InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H/i1D3;

SMILES Code

[2H]C([2H])(NCCCC12CCC(C3=C2C=CC=C3)C4=CC=CC=C14)[2H].Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.