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LY2607540

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Specification

Cat. No.

SMD961

Related Diseases

Depression

Product Name

LY2607540

Size

Customizable

Price

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Description

LY2607540, also known as THIIC, is a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties (EC(50) = 23 and 13 nM, respectively). THIIC produced anxiolytic-like efficacy in the rat stress-induced hyperthermia assay and the mouse stress-induced elevation of cerebellar cGMP and marble-burying assays. THIIC also produced robust activity in three assays that detect antidepressant-like activity, including the mouse forced-swim test, the rat differential reinforcement of low rate 72-s assay, and the rat dominant-submissive test, with a maximal response similar to that of imipramine.

CAS Number

1204737-09-6 (free base)

Chemical Formula

C24H24F3N3O4

Exact Mass

475.1719

Molecular Weight

475.4682

Elemental Analysis

C, 60.63; H, 5.09; F, 11.99; N, 8.84; O, 13.46

Synonym

LY2607540; LY-2607540; LY 2607540; THIIC

IUPAC/Chemical Name

N-({4-[3-hydroxy-4-(2-methylpropanoyl)-2-(trifluoromethyl)phenoxymethyl]phenyl}methyl)-1-methyl-1H-imidazole-4-carboxamide

InChi Key

RYINQFMHVVYWNS-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H24F3N3O4/c1-14(2)21(31)17-8-9-19(20(22(17)32)24(25,26)27)34-12-16-6-4-15(5-7-16)10-28-23(33)18-11-30(3)13-29-18/h4-9,11,13-14,32H,10,12H2,1-3H3,(H,28,33)

SMILES Code

O=C(C1=CN(C)C=N1)NCC2=CC=C(COC3=CC=C(C(C(C)C)=O)C(O)=C3C(F)(F)F)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.