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LY-341495

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Specification

Cat. No.

SMD585

Related Diseases

Bipolar Disorder

Related Diseases

Schizophrenia

Related Diseases

Depression

Product Name

LY-341495

Size

5.0mg; 25.0mg

Price

Inquiry

Availability

2 Weeks

Description

LY 341495 is a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3). Ki/IC50 values of LY-341495 are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8 , mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively. It is used in scientific research in several different areas, showing antidepressant effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the analgesic effects of μ-opioid agonists, as well as modulating dopamine receptor function.

CAS Number

201943-63-7

Chemical Formula

C20H19NO5

Exact Mass

353.1263

Molecular Weight

353.374

Elemental Analysis

C, 67.98; H, 5.42; N, 3.96; O, 22.64

Synonym

LY-341495; LY 341495; LY341495.

IUPAC/Chemical Name

(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid

InChi Key

VLZBRVJVCCNPRJ-KPHUOKFYSA-N

InChi Code

InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1

SMILES Code

O=C(O)[C@]([C@@H]1[C@@H](C(O)=O)C1)(N)CC2C3=C(OC4=C2C=CC=C4)C=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.