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Lu AF21934

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Specification

Cat. No.

SMD936

Related Diseases

Depression

Product Name

Lu AF21934

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; Click to view more sizes and prices

Price

Inquiry

Availability

2 Weeks

Description

Lu AF21934 is a positive allosteric modulator of mGlu4 receptors. Lu AF21934 reduces the harmaline-induced hyperactivity but not tremor in rats. The actions of Lu AF21934 are 5-HT1A receptor-dependent. Activation of the mGlu4 receptor may be a promising mechanism for the development of novel antipsychotic drugs, efficacious toward positive, negative, and cognitive symptoms.

CAS Number

1445605-23-1

Chemical Formula

C14H16Cl2N2O2

Exact Mass

314.0589

Molecular Weight

315.194

Elemental Analysis

C, 53.35; H, 5.12; Cl, 22.49; N, 8.89; O, 10.15

Synonym

Lu AF21934; Lu AF-21934; Lu AF 21934; Lu-AF21934; Lu-AF-21934; Lu-AF 21934; LuAF21934; LuAF-21934; LuAF 21934;

IUPAC/Chemical Name

(1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide

InChi Key

AVKZWCJNDWOBAM-ZJUUUORDSA-N

InChi Code

InChI=1S/C14H16Cl2N2O2/c15-11-6-5-8(7-12(11)16)18-14(20)10-4-2-1-3-9(10)13(17)19/h5-7,9-10H,1-4H2,(H2,17,19)(H,18,20)/t9-,10+/m1/s1

SMILES Code

O=C([C@@H]1[C@H](C(N)=O)CCCC1)NC2=CC=C(Cl)C(Cl)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.