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Loxapine-d8

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Specification

Cat. No.

SMD583

Related Diseases

Bipolar Disorder

Related Diseases

Schizophrenia

Related Diseases

Depression

Product Name

Loxapine-d8

Size

1.0mg

Price

Inquiry

Availability

2 Weeks

Description

Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic. It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

CAS Number

1189455-63-7

Chemical Formula

C18H10D8ClN3O

Exact Mass

335.1641

Molecular Weight

335.8608

Elemental Analysis

C, 64.37; H, 7.80; Cl, 10.55; N, 12.51; O, 4.76

Synonym

Loxapine-d8; Loxapine d8;

IUPAC/Chemical Name

2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine

InChi Key

XJGVXQDUIWGIRW-JNJBWJDISA-N

InChi Code

InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3/i8D2,9D2,10D2,11D2

SMILES Code

ClC1=CC2=C(OC3=C(N=C2N4C([2H])(C([2H])(N(C([2H])(C4([2H])[2H])[2H])C)[2H])[2H])C=CC=C3)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.