Ace Therapeutics is committed to providing lipid peroxidation measurements for the study of psychiatric disorders, including the assessment of isoprostane and malondialdehyde or thiobarbituric acid reactive substances in various biological fluids. We are committed to providing biomedical researchers with the best services available for analyzing lipid peroxidation reactions to help accelerate your drug development process for psychiatric disorders.

Introduction of Lipid Peroxidation in Psychiatry

The brain is known to be sensitive to oxidative stress and lipid peroxidation responses. Recent research data suggest that oxidative damage and lipid peroxidation are seen in major depression, bipolar disorder, and schizophrenia. In some cases, the mechanism of action of oxidative stress may be related to increased membrane lipid peroxidation. For example, ethane levels have recently been found to be elevated in schizophrenia, a direct marker of n-3 lipid peroxidation. Preclinical lipid peroxidation studies have helped to investigate whether measures of lipid peroxidation and oxidative stress can be used to determine the risk of developing various psychiatric disorders and whether long-term disease outcomes can be modified by interventions that reduce reactive oxygen species.

Fig. 1 Schematic illustration of the involvement of oxidative stress in schizophrenia. (Bitanihirwe BK, et al., 2011)

Lipid Peroxidation Analysis Services

Ace Therapeutics offers reliable, user-friendly assays to detect the most common lipid peroxidation byproducts, including malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) and 8-iso-prostaglandin F2-alpha (8-isoprostane). We are committed to helping you study lipid peroxidation in the central nervous system, as well as supporting the study of the link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder and major depression. The data we provide will support you in further studies of lipid peroxidation to discover therapeutic targets and biomarkers for psychiatric disorders.

Principle

Taking the detection of MDA as an example, lipid peroxidation is measured by the reaction of MDA with thiobarbituric acid (TBA) to form a colorimetric (532 nm)/fluorescent (λex=532/λem=553 nm) product, proportional to the presence of MDA.

What Can We Help You Achieve in Psychiatry?

1.Study of lipid peroxidation in schizophrenia

• Analysis of self-indirected markers of lipid peroxidation in schizophrenia, such as superoxide dismutase (SOD), catalase and detection of glutathione peroxidase activity
• Investigating the association between SOD activity and schizophrenia progression
• Detection of plasma thiobarbituric acid-reactive substances

2.Study of lipid peroxidation in bipolar disorder

• Detection of malondialdehyde levels in biological fluids
• Detection of mitochondrial dysfunction and oxidative status
• Studying the role of lipid peroxidation in bipolar disorder

3.Study of lipid peroxidation in major depressive disorder

• Study of lipid peroxidation targets in major depression
• Analysis of glutathione peroxidase and superoxide dismutase levels
• Analyzing the role of lipid peroxidation in major depressive disorder

Ace Therapeutics is committed to being the trusted solution provider of choice. Our advanced technology and experienced staff are dedicated to advancing your anti-psychotic drug development program and reducing overall development time. Our dedicated research team provides customized lipid peroxidation analysis based on your needs. For more information, please feel free to make an inquiry.

Reference

1. Bitanihirwe BK, Woo TU. Oxidative stress in schizophrenia: an integrated approach. Neurosci Biobehav Rev. 2011, 35(3):878-893.