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Lecozotan HCl

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Specification

Cat. No.

SMD254

Related Diseases

Anxiety

Product Name

Lecozotan HCl

Size

Customizable

Price

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Description

Lecozotan, also known as SRA-333, is a potent and selective 5-HT antagonist potentially for the treatment of Alzheimer's disease. Lecozotan (SRA-333) enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. Chronic administration of lecozotan did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model indicative of 5-HT(1A) receptor function. Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression.

CAS Number

433282-68-9 (HCl)

Chemical Formula

C28H30ClN5O3

Molecular Weight

520.03

Elemental Analysis

C, 64.67; H, 5.82; Cl, 6.82; N, 13.47; O, 9.23

Synonym

SRA-333; SRA333; SRA 333; Lecozotan HCl; Lecozotan hydrochloride.

IUPAC/Chemical Name

Benzamide, 4-cyano-N-((2R)-2-(4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)-N-2-pyridinyl-, monohydrochloride

InChi Key

GXYZREDEYDFJPT-ZMBIFBSDSA-N

InChi Code

InChI=1S/C28H29N5O3.ClH/c1-21(31-13-15-32(16-14-31)24-5-4-6-25-27(24)36-18-17-35-25)20-33(26-7-2-3-12-30-26)28(34)23-10-8-22(19-29)9-11-23;/h2-12,21H,13-18,20H2,1H3;1H/t21-;/m1./s1

SMILES Code

O=C(N(C[C@H](N1CCN(C2=C3OCCOC3=CC=C2)CC1)C)C4=NC=CC=C4)C5=CC=C(C#N)C=C5.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.