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L-733,060 HCl salt

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Specification

Cat. No.

SMD940

Related Diseases

Depression

Product Name

L-733,060 HCl salt

Size

Customizable

Price

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Description

L-733060 or L-733,060 is an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury.[15][16] It also has anticancer effects in a variety of in vitro models.

CAS Number

148687-76-7 (HCl)

Chemical Formula

C20H20ClF6NO

Molecular Weight

439.8264

Elemental Analysis

C, 54.62; H, 4.58; Cl, 8.06; F, 25.92; N, 3.18; O, 3.64

Synonym

L-733,060; L733,060; L 733,060; L-733060; L733060; L 733060; L-733060 HCl salt.

IUPAC/Chemical Name

(2S,3S)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenylpiperidine hydrochloride

InChi Key

DYEUTIUITGHIEO-APTPAJQOSA-N

InChi Code

InChI=1S/C20H19F6NO.ClH/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14;/h1-3,5-6,9-11,17-18,27H,4,7-8,12H2;1H/t17-,18-;/m0./s1

SMILES Code

FC(C1=CC(C(F)(F)F)=CC(CO[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)=C1)(F)F.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.