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L-368899 free base

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Specification

Cat. No.

SMD456

Related Diseases

Autism

Product Name

L-368899 free base

Size

Customizable

Price

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Description

L-368899 is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). L-368,899 HCl antagonizes oxytocin-induced uterine contractions in vitro and in vivo.

CAS Number

148927-60-0 (free base)

Chemical Formula

C26H42N4O5S2

Exact Mass

554.2597

Molecular Weight

554.76

Elemental Analysis

C, 56.29; H, 7.63; N, 10.10; O, 14.42; S, 11.56

Synonym

L-368899 free base; L-368,899; L-368,899; L-368,899; L-368899; L-368899; L-368899.

IUPAC/Chemical Name

(2R)-2-amino-N-((1R,4R)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide

InChi Key

MWIASLNTAGRGGA-OGUNDUEHSA-N

InChi Code

InChI=1S/C26H42N4O5S2/c1-19-7-5-6-8-22(19)29-12-14-30(15-13-29)37(34,35)18-26-11-9-20(25(26,2)3)17-23(26)28-24(31)21(27)10-16-36(4,32)33/h5-8,20-21,23H,9-18,27H2,1-4H3,(H,28,31)/t20-,21-,23?,26+/m1/s1

SMILES Code

O=C(NC1[C@@](C2(C)C)(CS(=O)(N3CCN(C4=CC=CC=C4C)CC3)=O)CC[C@]2([H])C1)[C@H](N)CCS(=O)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.