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JP-1302 HCl

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Specification

Cat. No.

SMD914

Related Diseases

Depression

Product Name

JP-1302 HCl

Size

Customizable

Price

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Description

JP 1302 dihydrochloride is a α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). JP 1302 dihydrochloride potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

CAS Number

1259314-65-2 (HCl)

Chemical Formula

C24H26Cl2N4

Molecular Weight

441.4

Elemental Analysis

C, 65.31; H, 5.94; Cl, 16.06; N, 12.69

Synonym

JP 1302 dihydrochloride; JP-1302 HCl; JP1302; JP-1302; JP 1302.

IUPAC/Chemical Name

N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

InChi Key

VVZOADYFJAJZGL-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H24N4.2ClH/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24;;/h2-13H,14-17H2,1H3,(H,25,26);2*1H

SMILES Code

CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=CC=CC=C53)C=C2)CC1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.