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J147 E-isomer

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Specification

Cat. No.

SMD933

Related Diseases

Depression

Product Name

J147 E-isomer

Size

Customizable

Price

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Description

J-147 is an E-isomer of J147 (Cat#522384). J147 is a potent neuroprotective and neurotrophic compound. J147 protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). J147. J147 reverses cognitive impairment in aged Alzheimer's disease mice. J147 is an exciting new compound that is extremely potent, safe in animal studies and orally active. J147 is a potential AD therapeutic due to its ability to provide immediate cognition benefits, and it also has the potential to halt and perhaps reverse disease progression in symptomatic animals as demonstrated in these studies.

CAS Number

1807913-16-1 (E-isomer)

Chemical Formula

C18H17F3N2O2

Exact Mass

350.1242

Molecular Weight

350.3412

Elemental Analysis

C, 61.71; H, 4.89; F, 16.27; N, 8.00; O, 9.13

Synonym

J147 E-isomer; J-147; J 147; J147;

IUPAC/Chemical Name

Acetic acid, 2,2,2-trifluoro-, (2E)-1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

InChi Key

HYMZAYGFKNNHDN-SSDVNMTOSA-N

InChi Code

InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+

SMILES Code

O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.