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Itasetron

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Specification

Cat. No.

SMD200

Related Diseases

Anxiety

Product Name

Itasetron

Size

Customizable

Price

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Description

Itasetron is a potent 5HT-3 receptor antagonist. Itasetron hydrochloride is a new 5-hydroxytryptamine3 (5-HT3) antagonist with potent antiemetic properties. It is more potent than ondansetron in animal models and in early clinical studies it demonstrates a long half-life and does not undergo hepatic biotransformation before elimination. itasetron hydrochloride is effective in the dose range 35-280 microg/kg in preventing cisplatin-induced emesis.

CAS Number

123258-84-4 (free base)

Chemical Formula

C16H20N4O2

Exact Mass

300.1586

Molecular Weight

300.36

Elemental Analysis

C, 63.98; H, 6.71; N, 18.65; O, 10.65

Synonym

Itasetron; DAU 6215CL; DAU6215CL; U 98079A; U-98079A; UNII-00S0D0OEKR;

IUPAC/Chemical Name

1H-Benzimidazole-1-carboxamide, 2,3-dihydro-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo, endo-

InChi Key

RWXRJSRJIITQAK-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H20N4O2/c1-19-11-6-7-12(19)9-10(8-11)17-15(21)20-14-5-3-2-4-13(14)18-16(20)22/h2-5,10-12H,6-9H2,1H3,(H,17,21)(H,18,22)

SMILES Code

O=C(N1C2=CC=CC=C2NC1=O)NC3CC(N4C)CCC4C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.