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Isoguvacine HCl

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Specification

Cat. No.

SMD454

Related Diseases

Autism

Related Diseases

Anxiety

Product Name

Isoguvacine HCl

Size

250.0mg; 500.0mg; 1.0g

Price

Inquiry

Availability

2 Weeks

Description

Isoguvacine is a GABAA receptor agonist. It binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay. It inhibits CA1 population spikes in rat hippocampal slices and high potassium/low magnesium-induced seizures in rat pups. Chronic administration of isoguvacine improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).

CAS Number

68547-97-7

Chemical Formula

C6H10ClNO2

Exact Mass

163.04

Molecular Weight

163.601

Elemental Analysis

C, 44.05; H, 6.16; Cl, 21.67; N, 8.56; O, 19.56

Synonym

Isoguvacine HCl;

IUPAC/Chemical Name

1,2,3,6-tetrahydropyridine-4-carboxylic acid hydrochloride

InChi Key

SUWREQRNTXCCBL-UHFFFAOYSA-N

InChi Code

InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H

SMILES Code

O=C(O)C1=CCNCC1.Cl

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.