Ace Therapeutics provides in vivo electrophysiology services for neurobiological studies of antipsychotic drugs. We are dedicated to helping you study the relationship between antipsychotic drugs and the emotional dynamics and brain circuits associated with emotions through electrophysiological signals.

Introduction of In Vivo Electrophysiological Analysis in Psychiatry

In vivo electrophysiology is critical for elucidating important properties of the nervous system associated with psychiatric disorders. Advances in systems neuroscience and brain electrophysiology include the increased importance of larger collections of coordinated neurons and the ability of neural oscillations to coordinate local and distant neuronal populations for more precise control of information flow. Focusing on the neurobiological electrophysiology of antipsychotic drugs and arguing for increased electrophysiological studies in animals responding to antidepressants may deepen understanding of these drugs and limbic circuits more generally.

Fig. 1 In vivo electrophysiological analysis of mPFC neurons. (Sparta DR, et al., 2014)

In Vivo Electrophysiological Analysis Services

• Electroencephalography (EEG) in Psychiatry

We offer EEG analysis services designed for animal studies of psychiatric disorders, including pharmaco-EEG and sleep-EEG. pharmaco-EEG can be used to study the effects of CNS-active compounds on brain activity. sleep-EEG can be used to measure impaired sleep continuity, disinhibition of REM sleep, and changes in non-REM sleep and wakefulness. changes in REM sleep and arousal.

• Electromyography (EMG) in Psychiatry

We offer a range of services related to the wireless recording of EMG neuronal activity in free-ranging mice. We can automatically and accurately track minute movements by measuring EMG. By combining EEG with EMG, we can more accurately characterize psychiatric disease phenotypes and putative drug responses.

• Electrocardiography (ECG) in Psychiatry

We offer rapid, non-invasive solutions for recording ECGs in conscious mice, rats and guinea pigs. Applications include diagnosis of psychiatric disorders (e.g., anxiety disorders), detection of adverse cardiac effects of psychotropic drugs, and drug screening for psychiatric disorders.

• Deep Brain Stimulation (DBS) in Psychiatry

We provide customized and efficient mapping protocols for DBS services, optimizing lead placement to maximize treatment benefits and minimize side effects. We are committed to helping researchers understand cognitive function about existing DBS targets, explore the neural mechanisms behind behavioral effects and evaluate new therapies for psychiatric disorders.

• Long-Term Potentiation (LTP) in Psychiatry

We offer LTP recording services designed specifically for animal studies of psychiatric disorders. We are committed to providing you with an exceptional macroscopic view of natural neuronal networks with rapid turnover capabilities through multiple LTP recordings and electrode array recordings to help you confirm the activity of your target compounds or study their mechanism of action.

Ace Therapeutics would love to chat with you! make an inquiry to discuss how our in vivo electrophysiology services can bring new key insights to your project or to request a quote.

Reference

1. Sparta DR, et al. Activation of prefrontal cortical parvalbumin interneurons facilitates extinction of reward-seeking behavior. J Neurosci. 2014, 34(10):3699-3705.