In vitro pharmacodynamic assessment is an essential tool for validating the activity of potential antipsychotics and providing a foundation for IND filing. In vitro pharmacodynamic screening and functional assays are crucial in the early discovery phase of antipsychotics. Ace Therapeutics' experienced experts will customize a complete in vitro pharmacodynamic evaluation solution for you, including cell-based assays, biochemical analyses, receptor binding assays, and more. We are committed to meeting your assay needs to optimize and accelerate your preclinical antipsychotic development program.

Our In Vitro Pharmacodynamic Assessment Services

• Cell model construction and screening

We offer a variety of validated cell lines, including transgenic and transgenic cell lines, glial cell lines, primary rat peripheral and central nervous system neurons at different developmental stages, and more. These models are able to mimic the mechanism of drug action in the human body. With the high-throughput screening platform, we can rapidly assess the affinity and selectivity of drug candidates for specific targets, providing critical data for further drug research.

• In vitro efficacy assessment

We provide an in-depth understanding of drug mechanisms of action and potential side effects through a series of enzyme activity assays, receptor binding assays, signaling pathway analyses, and biomarker analyses in blood, cerebrospinal fluid, and tissue samples collected from in vivo rodent studies. These tests include, but are not limited to:

• Gene and expression receptor analysis.
• Molecular mechanism studies and signaling pathway delivery studies.
• Gene expression studies and pathway dysfunction associated with mitochondrial metabolism and oxidative stress.
• Neurodevelopmental pathway studies.
• Basic biochemical studies of cell function and disease processes.
• Toxicity studies and determination of biological or biochemical activity of compounds.

Why Choose Us?

• Team of experts: We have an experienced neuropharmacology research team with in-depth understanding of psychiatric research and development.
• Advanced technology: A variety of validated cell lines and assays can provide you with accurate and reliable analysis data.
• Rich experience: We have accumulated a large number of in vitro assessment of antipsychotics to provide high-quality services to our clients.
• Customized solutions: We provide customized solutions and experimental designs according to customer needs.

Our Service Process

As a professional preclinical drug discovery and development company for psychiatric disorders, we are dedicated to providing comprehensive, customized services to assist our clients in evaluating the safety and efficacy of their drugs. The following outlines the detailed process of our services:

Ace Therapeutics is dedicated to providing comprehensive in vitro analytical services to assist you in evaluating the pharmacological properties of potential antipsychotic drugs, thereby accelerating your antipsychotic drug development program. For further information on our services, please do not hesitate to contact us. Our team of experienced experts will collaborate with you to provide customized solutions.