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Igmesine Hydrochloride

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Specification

Cat. No.

SMD897

Related Diseases

Depression

Product Name

Igmesine Hydrochloride

Size

Customizable

Price

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Description

Igmesine, also known as JO-1784 and CI1019, is a selective and potent σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). It inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Igmesine Hydrochloride is a weak inhibitor of brain 5-HT uptake in vitro. It exhibits neuroprotective and antidepressant effects.

CAS Number

130152-35-1 (HCl)

Chemical Formula

C23H30ClN

Molecular Weight

355.94

Elemental Analysis

C, 77.61; H, 8.50; Cl, 9.96; N, 3.94

Synonym

Igmesine Hydrochloride; Igmesine HCl; CI 1019; CI-1019; JO-1784; JO 1784; JO1784.

IUPAC/Chemical Name

(+)-(E)-N-(Cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)benzenemethanamine hydrochloride

InChi Key

SCHQQPAJNUHKSV-RSGUCCNWSA-N

InChi Code

InChI=1S/C23H29N.ClH/c1-3-23(22-14-8-5-9-15-22,24(2)19-21-16-17-21)18-10-13-20-11-6-4-7-12-20;/h4-15,21H,3,16-19H2,1-2H3;1H/b13-10+;

SMILES Code

CN(CC1CC1)C(C/C=C/C2=CC=CC=C2)(CC)C3=CC=CC=C3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.