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Harmalol HCl hydrate

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Specification

Cat. No.

SMD852

Related Diseases

Depression

Product Name

Harmalol HCl hydrate

Size

100.0mg; 250.0mg; 500.0mg

Price

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Availability

2 Weeks

Description

Harmalol HCl hydrate is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities. It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM). It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts. It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM. This product is also available as an analytical reference standard.

CAS Number

6028-00-8

Chemical Formula

C12H17ClN2O3

Molecular Weight

272.73

Elemental Analysis

C, 52.85; H, 6.28; Cl, 13.00; N, 10.27; O, 17.60

Synonym

11-hydroxy Harmalan; Harmidol; Harmalol; Harmalol hydrochloride hydrate; 11hydroxy Harmalan; 11 hydroxy Harmalan

IUPAC/Chemical Name

1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol hydrochloride dihydrate

InChi Key

OYKGNQNESCZSHQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H12N2O.ClH.2H2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12;;;/h2-3,6,14-15H,4-5H2,1H3;1H;2*1H2

SMILES Code

OC1=CC=C2C(NC3=C2CCN=C3C)=C1.Cl.O.O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.