The gut flora has extensive interconnections with the human brain through microbial metabolites, the vagus nerve, as well as hormonal and immune signaling, which together form the microbiome-gut-brain axis. Ace Therapeutics is committed to applying our expertise to help our clients elucidate the role of the microbiome in the onset and progression of psychiatric disorders, thereby providing scientific support for the development of medications for psychiatric disorders.

Importance of The Gut Microbiota in Psychiatric Disorders

There is a growing interest in the potential role of the gut microbiota in mental illness. Studies have demonstrated a correlation between the gut microbiota and mood, cognitive function, and the nervous system. Additionally, there is a link between the gut microbiota and anxiety, depression, autism, and other psychiatric disorders. These findings indicate that the gut microbiota may play a significant role in mental health and disease development. They offer new insights into the pathogenesis of psychiatric disorders and the development of new therapeutic strategies.

Fig. 1 The relationships of gut microbiota and mental disorders. (Xiong, R. G.; et al., 2023)

Our Gut Microbiome Research Services for Psychiatric Disorders

At Ace Therapeutics, we establish animal models of different mental disorders, such as anxiety, depression, and autism, for our clients according to their research demands. Next, through microbiome sequencing, data analysis and interpretation, we help our clients gain a deeper understanding of the relationship between the gut microbiome and psychiatric disorders, providing new ideas and methods for disease prevention, diagnosis and treatment.

Our comprehensive portfolio of services can help clients access the following key information:

• Information on the composition and function of gut microbes in diseased animals.
• Composition and changes in the microbiota at different stages of development of psychiatric disorders.
• How the gut microbiota affects neurotransmitter synthesis and secretion.
• How the gut microbiota affects neuropeptide concentration and function.
• How the gut flora modulates the function of the gut barrier and blood-brain barrier, affecting the brain through immune pathways.
• How bioactive substances produced by the microbiota affect the microbiota-gut-brain axis.

Our Service Process

• Project design

We provide customized research plans and implementations based on the client's research objectives.

• Animal modeling

Depending on the research program, we provide guidance and support in the establishment of animal models. This may involve selection of appropriate animal species, induction of psychiatric models such as stress, depression or anxiety models, etc.

• Sample collection

We provide instructions and methods for sample collection, including fecal sample collection or endoscopic acquisition of intestinal tissue samples.

• Microbiome analysis

We use advanced sequencing technologies, such as 16S rRNA sequencing or macro-genomic sequencing, to sequence the microbial DNA in our samples. These sequencing methods provide detailed information on microbial composition and function.

• Results delivery

We will assist the researcher in interpreting the results of the study and provide a detailed report.

If you are interested in our services, please contact us. Our team of experts will contact you within one business day to discuss your demands.

References

1. Xiong, R. G., et al. The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as The Protective Effects of Dietary Components. Nutrients. 15.14 (2023): 3258.
2. Singh, J.; et al. Microbiota-Brain Axis: Exploring the Role of Gut Microbiota in Psychiatric Disorders-A Comprehensive Review. Asian Journal of Psychiatry. (2024): 104068.