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Guanfacine HCl

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Specification

Cat. No.

SMD006

Related Diseases

ADHD

Product Name

Guanfacine HCl

Size

100.0mg; 200.0mg; 500.0mg; 1.0g

Price

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Availability

2 Weeks

Description

Guanfacine, also known as BS 100-141 and SPD-503, is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension (not to be confused with guaifenesin, an expectorant). It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. Guanfacine is currently approved and marketed in the United States[8] and Europe[9] as Intuniv for the treatment of ADHD in children and adolescents aged 6–18 years.

CAS Number

29110-48-3 (HCl)

Chemical Formula

C9H10Cl3N3O

Molecular Weight

282.549

Elemental Analysis

C, 38.26; H, 3.57; Cl, 37.64; N, 14.87; O, 5.66

Synonym

BS 100-141; BS-100-141; BS100-141; SPD-503; SPD 503; SPD503; Guanfacine HCl. brand name Estulic, Tenex and the extended release Intuniv

IUPAC/Chemical Name

N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride

InChi Key

DGFYECXYGUIODH-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

SMILES Code

O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.