Related Diseases
Schizophrenia
Size
50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g
Description
GTS-21, also known as DMBX-A, is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.
CAS Number
156223-05-1 (HCl)
Chemical Formula
C19H22Cl2N2O2
Elemental Analysis
C, 59.85; H, 5.82; Cl, 18.59; N, 7.35; O, 8.39
Synonym
GTS-21 HCl; GTS-21 hydrochloride; GTS-21; GTS 21; GTS21; DMBX-A
IUPAC/Chemical Name
3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride
InChi Key
BXKYFUGAAFLYJL-BXGYHSFXSA-N
InChi Code
InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
SMILES Code
COC1=CC=C(/C=C2C(C3=CC=CN=C3)=NCCC/2)C(OC)=C1.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001