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GSK-189254 free base

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Specification

Cat. No.

SMD1525

Related Diseases

Schizophrenia

Product Name

GSK-189254 free base

Size

25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg

Price

Inquiry

Availability

2 Weeks

Description

GSK-189254 is a potent and selective H3-receptor inverse agonist. It has subnanomolar affinity for the H3 receptor and selectivity of over 10,000x for H3 over other histamine receptor subtypes. Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs.

CAS Number

720690-73-3 (free base)

Chemical Formula

C21H25N3O2

Exact Mass

351.19468

Molecular Weight

351.45

Elemental Analysis

C, 71.77; H, 7.17; N, 11.96; O, 9.10

Synonym

GSK189254; GSK-189254; GSK 189254; GSK-189254 free base;

IUPAC/Chemical Name

6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)oxy)-N-methylnicotinamide

InChi Key

WROHEWWOCPRMIA-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H25N3O2/c1-22-21(25)17-6-8-20(23-14-17)26-19-7-5-15-9-11-24(18-3-2-4-18)12-10-16(15)13-19/h5-8,13-14,18H,2-4,9-12H2,1H3,(H,22,25)

SMILES Code

O=C(NC)C1=CN=C(OC2=CC=C3CCN(C4CCC4)CCC3=C2)C=C1

Appearance

solid powder

Purity

>98%

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.