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Gomisin D

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Specification

Cat. No.

SMD231

Related Diseases

Anxiety

Product Name

Gomisin D

Size

5.0mg

Price

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Availability

2 Weeks

Description

Gomisin D is a lignan that has been found in S. chinensis and has diverse biological activities, including enzyme inhibitory and antioxidant properties. It inhibits acetylcholinesterase (AChE) with an IC50 value of 7.84 µM. Gomisin D scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals. It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A3 by 89.9 and 83.1%, respectively, when used at a concentration of 100 µM. It is selective for UGT1A1 and UGT1A3 over other UGT isoforms at 100 µM.

CAS Number

60546-10-3

Chemical Formula

C28H34O10

Exact Mass

530.2152

Molecular Weight

530.57

Elemental Analysis

C, 63.39; H, 6.46; O, 30.15

Synonym

Gomisin D;

IUPAC/Chemical Name

(6R,7R,10S,18S,19S)-7,19-dihydroxy-12,13,14-trimethoxy-6,7,18,19-tetramethyl-6,7-dihydro-10H-10,15-propano[1,3]dioxolo[4',5':5,6]benzo[1,2-g]benzo[i][1,6]dioxacycloundecin-8(5H)-one

InChi Key

VLLFEMVDMFTBHG-KMIFWYFFSA-N

InChi Code

InChI=1S/C28H34O10/c1-13-8-15-9-18-22(37-12-36-18)24-19(15)20-16(10-17(32-5)21(33-6)23(20)34-7)25(27(13,3)30)38-26(29)28(4,31)14(2)11-35-24/h9-10,13-14,25,30-31H,8,11-12H2,1-7H3/t13-,14+,25-,27-,28+/m0/s1

SMILES Code

COC1=CC2=C(C3=C(C[C@@H]([C@](O)([C@]2(OC([C@@]4(O)C)=O)[H])C)C)C=C5C(OCO5)=C3OC[C@H]4C)C(OC)=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.