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FR-194921

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Specification

Cat. No.

SMD225

Related Diseases

Anxiety

Product Name

FR-194921

Size

Customizable

Price

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Description

FR-194921 is a new potent, selective, and orally active antagonist for central adenosine A1 receptors. FR194921 showed potent and selective affinity for the adenosine A1 receptor without affinity for A2A and A3 receptors and did not show any species differences in binding affinity profile among human, rat, and mouse. FR194921 exerts both cognitive-enhancing and anxiolytic activity, suggesting the therapeutic potential of this compound for dementia and anxiety disorders.

CAS Number

202646-80-8

Chemical Formula

C23H23N5O

Exact Mass

385.19026

Molecular Weight

385.46

Elemental Analysis

C, 71.67; H, 6.01; N, 18.17; O, 4.15

Synonym

FR-194921; FR 194921; FR194921.

IUPAC/Chemical Name

3(2H)-Pyridazinone, 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-

InChi Key

YHDRUTMZCJZJAL-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H23N5O/c1-26-15-12-18(13-16-26)28-21(29)11-10-19(24-28)22-20-9-5-6-14-27(20)25-23(22)17-7-3-2-4-8-17/h2-11,14,18H,12-13,15-16H2,1H3

SMILES Code

O=C1C=CC(C2=C3C=CC=CN3N=C2C4=CC=CC=C4)=NN1C5CCN(C)CC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.