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Fluparoxan HCl

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Specification

Cat. No.

SMD870

Related Diseases

Depression

Product Name

Fluparoxan HCl

Size

Customizable

Price

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Description

Fluparoxan, also known as GR-50360; GR-50360A, is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold). It was shown to possess central α2-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies.

CAS Number

105226-30-0 (HCl)

Chemical Formula

C10H11ClFNO2

Molecular Weight

231.6514

Elemental Analysis

C, 51.85; H, 4.79; Cl, 15.30; F, 8.20; N, 6.05; O, 13.81

Synonym

GR-50360; GR50360; GR 50360; GR-50360A; Fluparoxan hydrochloride

IUPAC/Chemical Name

(3aS,9aS)-5-fluoro-2,3,3a,9a-tetrahydro-1H-benzo[5,6][1,4]dioxino[2,3-c]pyrrole hydrochloride

InChi Key

JNYKORXHNIRXSA-OZZZDHQUSA-N

InChi Code

InChI=1S/C10H10FNO2.ClH/c11-6-2-1-3-7-10(6)14-9-5-12-4-8(9)13-7;/h1-3,8-9,12H,4-5H2;1H/t8-,9-;/m0./s1

SMILES Code

FC1=C2O[C@]3([H])[C@](OC2=CC=C1)([H])CNC3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.