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Fabomotizole mesylate

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Specification

Cat. No.

SMD198

Related Diseases

Anxiety

Product Name

Fabomotizole mesylate

Size

100.0mg; 250.0mg

Price

Inquiry

Availability

2 Weeks

Description

Fabomotizole, also known as Afobazole, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety.

CAS Number

Fabomotizole mesylate

Chemical Formula

C16H25N3O5S2

Exact Mass

343.1121

Molecular Weight

403.512

Elemental Analysis

C, 47.63; H, 6.25; N, 10.41; O, 19.82; S, 15.89

Synonym

Obenoxazine; Afobazol; Afobazole; Aphobazole; CM-346; CM346; CM 346; Fabomotizole; Fabomotizole mesylate

IUPAC/Chemical Name

4-(2-((5-ethoxy-1H-benzo[d]imidazol-2-yl)thio)ethyl)morpholine mesylate

InChi Key

KOGSOYODMCMSTR-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H21N3O2S.CH4O3S/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18;1-5(2,3)4/h3-4,11H,2,5-10H2,1H3,(H,16,17);1H3,(H,2,3,4)

SMILES Code

CCOC1=CC=C2NC(SCCN3CCOCC3)=NC2=C1.OS(=O)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.