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Fabomotizole dihydrochloride

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Specification

Cat. No.

SMD167

Related Diseases

Anxiety

Product Name

Fabomotizole dihydrochloride

Size

Customizable

Price

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Description

Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors.

CAS Number

189638-30-0 (2HCl)

Chemical Formula

C15H23Cl2N3O2S

Exact Mass

379.0888

Molecular Weight

380.33

Elemental Analysis

C, 47.37; H, 6.10; Cl, 18.64; N, 11.05; O, 8.41; S, 8.43

Synonym

Obenoxazine; Afobazol; Afobazole; Aphobazole; Fabomotizole dihydrochloride; CM-346; CM346; CM 346;

IUPAC/Chemical Name

1H-Benzimidazole, 6-ethoxy-2-((2-(4-morpholinyl)ethyl)thio)-, hydrochloride (1:2)

InChi Key

OFMVMQZFMVQDFO-UHFFFAOYSA-N

InChi Code

1S/C15H21N3O2S.2ClH/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18;;/h3-4,11H,2,5-10H2,1H3,(H,16,17);2*1H

SMILES Code

CCOc1ccc2c(c1)[nH]c(n2)SCCN3CCOCC3.Cl.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.