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Emapunil

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Specification

Cat. No.

SMD156

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Emapunil

Size

25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; Click to view more sizes and prices

Price

Inquiry

Availability

2 Weeks

Description

Emapunil, also known as AC-5216 and XBD-173, is a novel mitochondrial benzodiazepine receptor ligand (MBR ligand). AC-5216 showed high affinity for MBRs prepared from rat whole brain (Ki 0.297 nm), rat glioma cells (IC50 3.04 nm) and human glioma cells (IC50 2.73 nm), but only negligible affinity for the other main receptors including central benzodiazepine receptors. AC-5216 produced anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice at 0.1-3, 0.003-0.01 and 0.01-0.3 mg kg(-1), p.o., respectively.

CAS Number

226954-04-7

Chemical Formula

C23H23N5O2

Exact Mass

401.1852

Molecular Weight

401.47

Elemental Analysis

C, 68.81; H, 5.77; N, 17.44; O, 7.97

Synonym

AC-5216; AC 5216; AC5216; XBD-173; XBD 173; XBD173; Emapunil.

IUPAC/Chemical Name

N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

InChi Key

NBMBIEOUVBHEBM-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3

SMILES Code

O=C(N(CC)CC1=CC=CC=C1)CN2C(N(C)C3=CN=C(C4=CC=CC=C4)N=C23)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.