Electrophysiologic techniques are an indispensable tool in the diagnosis of psychiatric disorders. Ace Therapeutics is committed to applying our expertise and platform technologies to advance the study of neuro-biomarkers and EEG-based diagnostics for psychiatric disorders. Our one-stop service covers comprehensive solutions for electrophysiological index research, diagnostic tool development, and data analysis for psychiatric disorders. We aim to provide our clients with precise electrophysiological solutions to support diagnostic screening for psychiatric disorders, identify disease category subgroups, and facilitate response prediction.

Introduction of EEG-Based Diagnosis of Psychiatric Disorders

Electroencephalogram analysis is a very powerful tool in interpreting and diagnosing brain states, but it is not used in the diagnosis of psychiatric disorders due to its depth sensitivity and low spatial resolution. Recent methodological advances have demonstrated the potential of electrophysiological analysis for the classification and detection of psychiatric disorders.

For example, some event-related potentials, such as mismatch negativity, have been associated with neurocognition, function, and disease progression in schizophrenia. In addition, several EEG biomarkers have been widely evaluated in psychosis. Among them, mismatched negative waves (MMN) is a well-known EEG marker for schizophrenia associated with neurocognitive disorders in psychosis. These technological advances and research progress demonstrate the promise and significance of EEG in the precise diagnosis of psychiatric disorders.

Fig. 1 Schematic electroencephalograph (EEG) recording in humans and mice. (Cavanagh, J. F. et al., 2021)

Our Electrophysiologic Diagnostic Methods Development Services for Psychiatric Disorders

At Ace Therapeutics, we help our clients develop EEG biomarkers for electrophysiological diagnostic method development for psychiatric disorders through EEG analysis, machine learning algorithms, and animal models. Our services include but are not limited to:

• Data collection: Data on the EEG activity of an individual is collected through advanced electrophysiology equipment.
• Signal processing: We process the collected EEG data to improve the signal quality.
• Feature extraction: we analyze the EEG signals to extract features related to psychiatric disorders, such as oscillation patterns, oscillation frequencies, and functional connectivity.
• Machine learning model building: predictive modeling using machine learning algorithms to identify and validate EEG biomarkers.
• Biomarker validation: validation of the accuracy and reliability of the developed biomarkers using preclinical animal models.

Advantages of Our Electrophysiologic Diagnostic Methods Development Services

• A team of experienced experts provides one-stop customized services from project consulting to result in a verification.
• Development of EEG analysis methods with cost advantages and good accessibility.
• The entire development process follows a strict experimental procedure to ensure standardization of services and reproducibility of results.

Ace Therapeutics is committed to providing comprehensive solutions to support our clients' progress in the development of electrophysiologic approaches to psychiatric disorders. Please contact us for more details and we will be happy to assist you.

Reference

1. Cavanagh, J. F.; et al. Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms. Translational psychiatry. 11.1 (2021): 482.