Eating Disorders Animal Models

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Ace Therapeutics, as a drug discovery and development partner, has a mature animal model research and development platform. We are committed to providing customized services for eating disorders animal models for psychiatric research and helping researchers successfully achieve research goals.

Introduction of Eating Disorders Animal Models

Eating disorders, such as anorexia nervosa, bulimia nervosa, and binge eating, are described as disorders of eating habits. These abnormal eating patterns lead to energy imbalances that can damage an individual's health. For eating disorders, animal models are an important tool for studying eating behavior and its pathological forms.

Fig. 1 Research progress on the biological mechanism of eating disorders. (Stern SA, et al., 2020)

Animal Modeling Services for Eating Disorders

Ace Therapeutics has many years of experience in psychiatric disease research and a mature animal research and development platform. We offer a range of environmental and genetic animal models for the study of eating disorders that mimic some of the features of human psychiatric disorders and that accurately reproduce the alterations in feeding and neuroendocrine function that are unique to each eating disorder.

Information on animal models of depression we provide:

Table 1 Animal Models of Anorexia Nervosa.

Models	Characteristics
Self-starvation/Activity based anorexia (ABA) Models	ADHD, reduced food intake, weight loss, significantly lower leptin levels
Stress models	Does not control food supply, but can cause weight loss
Diet restriction	Chronic food restriction leads to reduced cognitive function, and tyrosine supplementation improves cognitive function without changing body weight
Genetic models
anx/anx mice	Weight loss, body shaking, head bobbing, hyperactivity, and uncoordinated gait
Dopamine deficient (DD) mice	Loss of appetite and activity
M3R^−/− mice	Decreased food intake and subsequent weight loss, low serum leptin and insulin levels, and markedly elevated total energy expenditure

Table 2 Animal Models of Bulimia nervosa/Binge Eating.

Models	Characteristics
Food restriction	When the animals lost 20-35% of their normal body weight, the animals exhibited marked binge eating, even in the fed state. This behavior can be induced without any other factors such as palatable food or environmental stressors.
Stress	Physical stress: fasting/refeeding paradigm is combined with food-shock stress with palatable foods, animals display binge-like increases in caloric intake. Environmental stress: post-natal maternal separation (MS), rodents under this stress exhibit depression and anxiety-like behaviors in adulthood with imbalances in serotonin levels.
Sham-feeding	Sham-feeding can be achieved with gastric fistula, by which liquid food can be drained from the opening before it enters the intestine. Under these conditions, rats show binge-like behavior consuming a large amount of food.

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Ace Therapeutics offers custom eating disorder animal models to help you further understand the underlying pathophysiology of anorexia nervosa and develop new treatments. Please tell us your project requirements, we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to make an inquiry.

References

Kim SF. Animal models of eating disorders. Neuroscience. 2012, 211:2-12.
Stern SA, Bulik CM. Alternative Frameworks for Advancing the Study of Eating Disorders. Trends Neurosci. 2020, 43(12):951-959.

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