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DuP-697

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Specification

Cat. No.

SMD805

Related Diseases

Depression

Product Name

DuP-697

Size

Customizable

Price

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Description

DuP-697, also known as S-6907 and BFMT, is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of rheumatoid arthritis (RA) and osteoarthritis. DuP-697 alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 significantly suppressed K562 cells and primary CML cells growth and induced apoptosis in a concentration-dependent manner and the growth-inhibiting effect was independent on Philadelphia chromosome. DuP-697, at concentrations ranges which do not inhibit PGHS-1 activity, significantly attenuated the inhibition of PGHS-1 that was caused by aspirin and indomethacin.

CAS Number

88149-94-4

Chemical Formula

C17H12BrFO2S2

Exact Mass

409.9446

Molecular Weight

411.3034

Elemental Analysis

C, 49.64; H, 2.94; Br, 19.43; F, 4.62; O, 7.78; S, 15.59

Synonym

DuP-697; DuP 697; DuP697; S-6907; S 6907; S6907; BFMT

IUPAC/Chemical Name

5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)thiophene

InChi Key

AJFTZWGGHJXZOB-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3

SMILES Code

O=S(C1=CC=C(C2=C(C3=CC=C(F)C=C3)SC(Br)=C2)C=C1)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.